Description
Product Characteristics:
With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6 % of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. The C5orf29 gene product has been provisionally designated C5orf29 pending further characterization.
Subcellular location: Cell membrane
Synonyms: C5orf29, Gapt, GAPT_HUMAN, Grb2-binding adaptor transmembrane, Growth factor receptor-bound protein 2-binding adapter protein, Growth factor receptor-bound protein 2-binding adapter protein, transmembrane, Protein GAPT, transmembrane.
Target Information: Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells